
A lifelong sufferer from depression, Burton's work can be seen as an attempt to write himself out of illness. But this is not merely a first-person account of sickness: Burton's Anatomy attempts to include every conceivable account of melancholy that was available to him. However, this is just the starting point: as from melancholy, Burton examines almost every topic imaginable: the Anatomy then, becoming an enormous compendium of medicine, philosophy, wit and legend – arguably a summation of human learning up to that date.
From its first publication in 1621, Burton expanded the Anatomy through five further editions before a posthumous edition came off the presses in 1652. Its influence on the next century of English Literature is clear and its properties were hailed by Samuel Johnson, who said reading the Anatomy provided solace during the darker moments of his own depression.

Wellcome Library readers can also access different editions of the Anatomy through Early English Books Online (EEBO), a remote access resource freely available to Library readers. Ideal reading material for 'Blue Monday' and - for some modern critics - every other day of the year.